138 articles - From Friday Apr 04 2025 to Friday Apr 11 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Gastroenterol |
|---|
| Endoscopy |
Curriculum for training in peroral endoscopic myotomy (POEM) in Europe (Part I): European Society of Gastrointestinal Endoscopy (ESGE) Position Statement. 7: POEM competence should reflect the technical success rate, both the short- and long-term clinical success rates, and the rate of true adverse events. 8: A POEM center should maintain a prospective registry of al procedures performed, including patient work-up and outcomes, procedural techniques, and adverse events. |
| J Hepatol |
Deceased donor liver utilisation and assessment: Consensus guidelines from the European Liver and Intestine Transplant Association. Online voting was held to approve statements according to a modified Delphi method; statements reaching ≥85% agreement were approved. Statements addressing liver utilisation, the definition of high-risk livers, and strategies and criteria for dynamic liver assessment are presented. |
EASL Clinical Practice Guidelines on TIPS. The aim of these EASL guidelines is to comprehensively address al aspects of TIPS in patients with cirrhosis. Other related topics, such as the use of TIPS in surgical settings and in vascular liver disorders, are covered in separate dedicated clinical practice guidelines. |
| J Neurogastroenterol Motil |
2025 Seoul Consensus on Clinical Practice Guidelines for Irritable Bowel Syndrome. The modified Delphi method was used to achieve expert consensus to adopt the core recommendations of the guidelines. These guidelines serve as a reference for clinicians (including primary care physicians, general healthcare providers, medical students, residents, and other healthcare professionals) and patients, helping them to make informed decisions regarding IBS management. |
meta-analyses and systematic reviews
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
High Global Prevalence of Steatotic Liver Disease and Associated Subtypes: a Meta-Analysis. Prevalence was notably elevated in individuals with type 2 diabetes (70.2%; 95% CI: 66.1-73.9; I2 = 65.4%) and in overweight/obese populations (70.7%; 95% CI: 43.2-88.4; I2 = 99.0%). The high prevalence of SLD shows that there remains an urgent need for targeted public health interventions and policies to address the modifiable risk factors contributing to the global burden of SLD. |
| Gastroenterology |
| J Neurogastroenterol Motil |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Biopsy-Sparing Diagnosis of Coeliac Disease Based on Endomysial Antibody Testing and Clinical Risk Assessment. Low-risk adult patients could have been safely diagnosed with coeliac disease non-invasively based on EmA without endoscopy and duodenal biopsy. Older patients with alarm symptoms should undergo endoscopy with duodenal biopsy to avoid missing non-coeliac enteropathies. Further validation of our results is necessary. |
Clinical Trial: Dose-Finding Study of Linaprazan Glurate, A Novel Potassium-Competitive Acid Blocker, Versus Lansoprazole for the Treatment of Erosive Oesophagitis. Linaprazan glurate demonstrated high 4-week healing rates compared to lansoprazole, with a good safety profile, supporting its further development. |
Extracellular Vesicles miRNome Profiling Reveals miRNAs Engagement in Dysfunctional Lipid Metabolism, Chronic Inflammation and Liver Damage in Subjects With Metabolic Dysfunction-Associated Steatotic Liver Disease. In addition, let-7d-5p and let-7f-5p inversely correlated with the circulating and hepatic expression of pro-inflammatory cytokines, which increased by increasing degrees of AT-IR. Our results suggest an intertwined connection between miR-122-5p, miR-375-3p, and the let-7 family in modulating lipid derangements and inflammatory pathways in patients with 'at-risk MASH', paving the basis for further studies aiming at investigating their potential therapeutic value. |
Immigration Factors and Monitoring of Chronic Hepatitis B Infection Among Foreign-Born: The FOCUS-HBV Multicentre Cohort. Adherence to long-term monitoring is suboptimal among a diverse cohort of immigrants with chronic HBV. More efforts to engage and retain immigrants in care are needed. |
Longitudinal Relationship Between Elevated Liver Biochemical Tests and Negative Clinical Outcomes in Primary Biliary Cholangitis: A Population-Based Study. Prolonged elevation of multiple hepatic biomarkers and fibrosis scores is associated with a greater risk of negative clinical outcomes, underscoring the importance of ongoing monitoring beyond the guideline-recommended initial treatment response to guide timely treatment decisions and improve PBC management. |
Real-World Effectiveness and Safety of Mirikizumab Induction Therapy in Patients With Ulcerative Colitis: A Multicentre Retrospective Observational Study. There were no adverse events leading to permanent discontinuation of mirikizumab or death. This real-world study demonstrated the short-term effectiveness and safety of mirikizumab in patients with UC. |
Risk of De Novo Inflammatory Bowel Disease in Patients With Psoriasis and Psoriatic Arthritis Treated With IL-17A Inhibitors: A Population-Based Study. Among 13,216 matched patients per group, 142 developed IBD with IL-17 inhibitors versus 60 with apremilast (aHR = 2.50, 95% CI: 1.85-3.39). IL-17 inhibitors increase IBD risk, necessitating careful patient selection and monitoring. |
Therapeutic Sequences of Systemic Therapy After Atezolizumab Plus Bevacizumab for Hepatocellular Carcinoma: Real-World Analysis of the IMMUreal Cohort. Sequential therapy following atezolizumab and bevacizumab is feasible only for selected patients. However, preserving liver function seems crucial to optimising multi-line therapy and improving outcomes in advanced hepatocellular carcinoma. |
| Am J Gastroenterol |
A Risk Stratification Tool for Relapse After Intravenous-to-Subcutaneous Switching of Infliximab in Patients with Inflammatory Bowel Diseases. Pre-switch infliximab clearance and fecal calprotectin are accurate predictors of relapse after switching to subcutaneous infliximab. An interactive risk stratification tool facilitates confirmation of a stratified medicine approach to improve infliximab therapy in IBD. |
Clinical and HLA associations of fluoroquinolone induced liver injury: results from the Drug-Induced Liver Injury Network. FQ DILI is a class effect that presents with a short latency, variable pattern of liver injury, and carries a significant risk of chronicity and mortality. There is a significant association with HLA-DQA1*03:01 and HLA B*57:01. |
Efficacy of Polysaccharide Hemostatic Powder on blood oozing among patients with Post-Endoscopic Sphincterotomy Bleeding: A Randomized Controlled Trial. PHP is not inferior to endoscopic clip and could be of use in immediate hemostasis for non-pulsatile post-EST bleeding, with the added advantage of ease of use. Further research is needed to assess its efficacy in preventing delayed bleeding. (chictr.org.cn, ChiCTR2400092280). |
Existential Reflections by Older Adults with Inflammatory Bowel Diseases on Medical and Surgical Treatments. Supporting older adults with IBD to feel less resigned with their disease is critical. Providers should consider redefining what "feeling normal" means to facilitate disease acceptance and present treatment information with minimal bias. |
Is Carbohydrate Intolerance associated with carbohydrate malabsorption in Disorders of Gut-Brain Interaction (DGBI)? Carbohydrate intolerance affects a substantial group of DGBI patients, impacting their quality of life and symptom severity. Further research is needed to explore the underlying mechanisms in patients who do not have carbohydrate malabsorption/maldigestion. |
PATIENT REPORTED OUTCOME MEASURES IN BENIGN ESOPHAGEAL DISORDERS. Future efforts should focus on creating user-friendly PROs that comprehensively evaluate not just clinical presentation but also the disease state, which will enhance clinical symptom follow-up, quality of life assessment and research applications. Assessments of hypervigilance and visceral anxiety will complement these applications as these measures are both a PRO and an important moderator of symptom severity and quality of life. |
The Impact of Cannabis Use in Gastroparesis: A Propensity Matched Analysis 41,374 gastroparesis patients. Cannabis use in gastroparesis patients appears to increase healthcare utilization. These findings underscore the need to carefully assess the risks and benefits of cannabis in gastroparesis management. Prospective studies are essential to evaluate cannabinoids' efficacy and safety in this context. |
The Utility of Multitarget Stool DNA Testing in Community-Based Clinical Practice. The rate of colon cancer detection (10/5,827 (0.2%) patients for whom it was ordered and 10/3,119 (0.3%) who completed the test) was lower than expected in a screening cohort. The majority of patients who completed MT-sDNA testing had a false positive result for advanced adenomas or CRC (73%). Together, these findings raise questions about the effectiveness of screening based on MT-sDNA testing in an average risk population. |
| Clin Gastroenterol Hepatol |
Biologic switch timing and risk of infection in patients with ulcerative colitis/Crohn's disease: a retrospective study. Overlapping switches were common and not associated with an increased risk of serious infection versus non-overlapping biologics. Shortened washout periods may pose minimal safety risks to patients while improving UC/CD therapy management and improving trial recruitment. |
Effect, tolerability, and safety of exclusive palatable elemental diet in patients with intestinal microbial overgrowth. PED significantly impacts the gut microbiome. Tolerance to EDs improve with enhanced palatability. Larger studies with longer follow-up are needed to assess response durability. (ClinicalTrials.gov ID NCT05978973). |
Steatotic liver disease classification is dynamic, affecting clinical trial eligibility and subclass-specific treatments. SLD and the subclassification hereof is highly dynamic, especially driven by changes in alcohol use and hepatic steatosis. This affects eligibility for clinical trials and clinical management of patients with SLD. |
| Endoscopy |
Assessment of the participation rate and effectiveness of upper gastrointestinal cancer screening in China: a multicenter population-based screening study. Participation in endoscopic screening among a high-risk UGIC population in China was low. We found that one-time endoscopic screening significantly reduced mortality caused by UGIC. |
Endoscopic balloon dilation with steroid injection versus radial incision and cutting with steroid for refractory esophageal anastomotic stricture: a randomized study. EBD combined with steroid injection is the standard treatment for refractory anastomotic stricture after esophagectomy. |
Simulators and training models for diagnostic and therapeutic gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Technical and Technology Review. In Part I, only mechanical simulators are reported and described. In Part II, animal simulators (ex vivo/in vivo) and virtual reality models are detailed, together with prototypes that are currently not commercially available. |
| Gastroenterology |
MASH Adipose Tissue Macrophages Secrete Extracellular Vesicles That Activate Liver Fibrosis in Obese Male Mice. Identification of the fibrogenic miRs, miR-155 and miR-34a, within MASH-ATM-sEVs, highlights the mechanistic importance of extrahepatic signals in MASH. These findings show the therapeutic potential of modulating macrophage phenotypes and their sEV cargo to ameliorate MASH. |
TL1A/DR3 signaling regulates the generation of pathogenic Th9 cells in experimental Crohn's disease. We demonstrate that functional DR3 receptor is essential for Th9 cell pathogenicity, revealing a new mechanism by which TL1A/DR3 signaling drives experimental CD-like ileitis. The TL1A/DR3/Th9 pro-inflammatory pathway may offer a novel therapeutic target for patients with CD. |
| Gastrointest Endosc |
Comparing the feasibility, safety, and efficacy of Stretta radiofrequency and anti-reflux ablation therapy for treating patients with refractory gastroesophageal reflux disease: A retrospective, single-center cohort study. Both groups showed similar improvements in GERDQ scores; however, SRF was more effective in terms of PPI withdrawal and caused fewer complications. In contrast, ARAT was better at improving Hill's valve grading and resolving Barrett's esophagus. |
| Gut |
Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19. We identified a possible manifestation of an immune-mediated postacute sequel to COVID-19 associated with a characteristic immune infiltrate in children with AHUO. COVID-19 testing should be considered in paediatric AHUO. |
Colorectal cancer incidence after the first surveillance colonoscopy and the need for ongoing surveillance: a retrospective, cohort analysis. Patients with high-risk findings at both baseline and SC1 needed an SC2, while those with low-risk findings at SC1 did not, regardless of their baseline findings. |
Opposite regulation of intestinal and intrahepatic CD8+ T cells controls alcohol-associated liver disease progression. ALD is associated with loss of duodenal CD8+ T cells but elevation of intrahepatic CD8+ T cells, which aggravates and ameliorates ALD, respectively. Restoration of survival and functions of intestinal and intrahepatic CD8+ T cells may represent a novel therapeutic strategy for ALD patients. |
Reactive cholangiocyte-derived ORM2 drives a pathogenic modulation of the injured biliary niche through macrophage reprogramming. Mechanistically, ORM2 effects were mediated by an inositol 1,4,5-trisphosphate receptor type 2-dependent calcium pathway. This study reveals a paracrine communication circuit during ductular reaction, in which reactive cholangiocyte-derived ORM2 reprogrammes liver macrophages, participating in a pathogenic remodelling of the immune biliary niche. |
| Hepatology |
Advances in imaging - Elastography. Spleen stiffness measurement (SSM) complements liver assessments, enhancing the identification of portal hypertension and refining patient risk stratification. This review covers current clinical applications but also anticipates future innovations such as artificial intelligence based algorithms that could expand elastography's clinical impact so improving patient outcomes. |
Cell therapies and liver organogenesis technologies: Promising strategies for end-stage liver disease. Notably, liver replacement technologies hold considerable potential for producing biologically functional and transplantable liver grafts. In this review, we discuss the fundamental principles and recent advancements in cell therapies and liver organogenesis technologies while also addressing the challenges and future prospects in this rapidly evolving field. |
Portal sinusoidal vascular diseases: Assessment and therapy. This review discusses methods for assessing PSVD, including clinical and histological features, imaging techniques, and currently available treatments. It also addresses the challenges posed by the new nomenclature and the remaining questions in disease assessment. |
Renin-angiotensin-aldosterone system inhibitor use improves clinical outcomes in patients with metabolic dysfunction-associated steatotic liver diseases: Target trial emulation using real-world data. ACEi/ARB use in patients with MASLD was associated with a reduced risk of mortality, MALO, and MACE compared to CCB use. A large prospective study is needed for external validation. |
Simulating the impact of survival benefit-based liver transplant organ allocation. Our simulations predicted that survival benefit-based allocation would only increase post-transplant survival by an average of 18 days per recipient, at the expense of a simulated increase in waitlist mortality of 400 deaths per year. The current practice of liver transplantation, with sickest-first allocation operating in a system where transplant physicians ration organs to maximize outcomes, survival benefit overall is maintained and not compromised. |
Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1. Analyses of human MASH samples revealed a positive correlation between IRE1 signaling and P4HB/PDIA1 expression as well as the severity of the disease. Altogether, our results establish a role of the IRE1/P4HB axis in the regulation of collagen production and support its implication in the pathogenesis of liver fibrosis. |
| J Hepatol |
Cisplatin-induced Disruption of Mitochondrial Divisome Leads to Enhanced Cisplatin Resistance in Cholangiocarcinoma. We proposes a novel feasible treatment strategy to reverse CDDP resistance in CCA through targeting mitochondria morphology. Our study highlights the importance of monitoring dynamic changes at the protein and organelle levels during anticancer treatment, providing robust evidence for functional precision oncology. Impact and implications This study identifies that high INF2 expression at baseline is associated with poor prognosis in cholangiocarcinoma (CCA) patients. Moreover, cisplatin-induced INF2 degradation via proteasomal and SEC62-mediated ER-phagy is revealed as a key driver of mitochondrial hyperfusion and chemoresistance in CCA. It establishes mitochondrial morphology targeting as a novel strategy to overcome chemotherapy resistance. Furthermore, this study emphasizes the need to focus on dynamic changes in tumor proteins or organelle functions during treatment (functional precise oncology), rather than limiting analysis to static tumor states. Given that inhibition of oncogenes may lead to potential resistance mechanisms, comprehensive preclinical evaluations are essential before clinical application. |
| J Neurogastroenterol Motil |
Association Between Caffeine Intake and Stool Frequency- or Consistency-Defined Constipation: Data From the National Health and Nutrition Examination Survey 2005-2010. Caffeine consumption is not associated with stool frequency or consistency-defined constipation. Nevertheless, increased caffeine intake may decrease the risk of constipation (defined by stool frequency) among participants in the high-cholesterol intake group. |
Association of Genetically Predicted Obesity and Stool Frequency: Evidence From an Observational and Mendelian Randomization Study. Obesity-related anthropometric indicators were causally associated with increased stool frequency in the overall and central obesity groups. Weight loss could be a potential approach to improve gastrointestinal regularity in individuals with obesity. |
Gastric Myoelectrical Activity Subtypes in Functional Dyspepsia and Gastroparesis. WLST-electrogastrography coupled with GE study may distinguish between normal/dysrhythmic GMA revealing pathophysiologicalphenotypes of GP and FD. Analysing extent of power change in normogastric, and dysrhythmic frequencies may comprehensively elucidate disease severity. |
Long-term Prognosis and Prognostic Factors in Ineffective Esophageal Motility. Patients with ineffective esophageal motility continue to experience long-term esophageal symptoms at follow-up. Provocative tests seem to have the potential to partly predict the long-term prognosis of dysphagia. |
Overlapping Reflux Symptoms in Functional Dyspepsia Are Mostly Unrelated to Gastroesophageal Reflux. Strikingly, these symptoms primarily diverged from reflux etiology and exhibited suboptimal responses to PPI intervention. These findings challenge prevailing paradigms and accentuate the imperative for nuanced therapeutic approaches tailored to the distinctive characteristics of overlapping reflux symptoms in the context of FD. |
Panenteric Transit Times and Contractile Activity in Diabetic Gastroenteropathy. Gastrointestinal transit times, as well as antral and colonic contractile activity, differed between individuals with diabetic gastroenteropathy and controls. The overall gastric contraction frequency was associated with symptom severity. |
Validation of the London Classification for Rectal Hyposensitivity in an Anorectal Manometry Database of 2540 Patients With Functional Defecatory Disorder. Defining RH based on 1 or more abnormal sensory thresholds showed better clinical correlation with patient characteristics. However, further prospective studies are needed to validate these findings before proposing revisions to the current London classification criteria. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
| Gastroenterology |
| Gastrointest Endosc |
| J Neurogastroenterol Motil |
Potassium-competitive Acid Blockers for Treatment of Extraesophageal Symptoms and Signs. Therefore, P-CABs appear to have a treatment role in extraesophageal symptoms and signs of GERD. However, considering that P-CABs are not superior to PPIs, large-scale, multi-center studies with double dose P-CABs over a prolonged period of time may elucidate a subgroup of patients in whom P-CABs are beneficial in ameliorating extraesophageal symptoms and signs. |
The Duodenal Microenvironment in Functional Dyspepsia. We discuss the potential triggers for these observed alterations, including psychological comorbidities, luminal alterations and food related triggers. In summary, this review presents the evidence of molecular and cellular changes in patients with FD, with an impaired duodenal barrier and activated mucosal eosinophils and mast cells, challenging the notion that FD is purely functional, and offering different targets for potential future treatments. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Endoscopy |
| Gastroenterology |
| Gut |
| Hepatology |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| J Hepatol |
| J Neurogastroenterol Motil |